- Darla Jean Hood
- Jack Egan - Jack the Assistant
- Nora Cecil - Miss Witherspoon
- Robert Winckler - Student
- Rosina Lawrence - Miss Jones
- Shirley Coates
- Sidney Bracey - O.T. Hertz
- Tommy McFarland - Student
Plot: Spanky, Alfalfa and Buckwheat are dreading another day of school when they hear that their teacher wants to attend her sister's wedding. Miss Witherspoon, the superintendant of schools, remarks that nothing short of an epidemic would justify closing school down so Spanky decides to create one. He sprays his, Alfalfa's and Buckwheat's faces with spots and inflates footballs under their shirts from the tire of a vehicle in the parking lot. They then march happily not to a local doctor but to the veterinary office of O.T. Hertz who suspiciously decides to check out Buckwheat's affliction, busting the deception in the process. Meanwhile, Hertz's discussion with his assistant over the treament of a monkey convinces Spanky and Alfalfa that the doctor has turned Buckwheat into a monkey. When they can't find Buckwheat, they find a monkey wearing his discarded sweater. Meanwhile, Porky has been trying with futile efforts to deliver a note to Spanky from Waldo. When Spanky finally reads the note, he learns any epidemic, real or otherwise, is not necessary; Miss Witherspoon has given Miss Jones permission for a few days off. Buckwheat now jumps excited from the news from the sack he's been hiding in the whole time.
- This short owes its plot and conception to the shorts A Lad An' A Lamp, Circus Fever and to an actual Christmas flu epidemic in Hollywood that occurred in 1936. The title is a spoof of "Three Smart Girls" by Henry Koster.
- Sidney Bracey also played Hobson the butler in Second Childhood
- Miss Jones is referred to as Miss Lawrence in this episode; this was the actress's real name.
- This was the last short for Rosina Lawrence as the gang's teacher.
- Apparently, Miss Jones is unable to get either of her predecessors, Miss Crabtree nor Miss Kornman to replace her in her absence.